Abstract
24 children with hypoglycemia shoved in average a concentration of adrenaline before tolbutamide provocation(30mg/kg) (T)pf 66±31, before insulin load(0.05U/kg) (I)of 46±16and of 55±17 pg/ml before ketogenic diet(K).In control children rangedthe basal adrenaline level between 81 and98 pg/ml(p 0.15). The adrenaline conc.rose in the controls to average values of 811 (T), 588(K)pg/Ml, and increased 6-fold duringI. The children with ketogenic hypoglycemia averaged peak values of adrenaline of 166(T), 194(I) and 184(K) pg/ml. Similar results were obtained in 12 other patients with spontaneous hypoglycemia (type Zetterstroem)(Z). Plasma alanine conc. averaged in controls332 umol/l, in children with ketogenic h. 219 umol/l(p 0.01). During ketogenic diet provokation the alanine level decreased in controls of 14.5%, in children with Z-hypoglycemia of 24%, in patients with ketogenic h. of 45.8%.
The low alanine concentrations may be caused by a diminished adrenaline liberation after hypoglycemic stimuli, whereas the decreased alanine concentration may be the cause for a decreased substrate availability for gluconeogenesis.
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Rager, K. Plasma levels of adrenaline and alanine in spontaneous hypoglycemia. Pediatr Res 12, 155 (1978). https://doi.org/10.1203/00006450-197802000-00057
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DOI: https://doi.org/10.1203/00006450-197802000-00057
