Abstract
Fourteen diabetic boys (five with family history of diabetes and nine without) and twenty-nine “short normal” boys were studied. A gonadal function test (2,000 IU of hCG im for three days and plasma testosterone assay before and after the hCG administration) as well as a LH-RH test (50 μg iv) were carried out. While basal testosterone turned out to be similar in the two groups of children, after hCG testosterone was significantly lower (p<0.01) than the mean value of the control group. This difference turned out to be primarily due to the patients with family history of diabetes. In the diabetic children the pituitary LH reserve, the basal FSH level and the FSH pituitary reserve were lower than in normal boys. These data demonstrate that in the diabetic child is already evident an alteration in the hypothalamo- pituitary-gonadal function.
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Cacciari, E., Cicognani, A., Pirazzoli, P. et al. Hypophyso-gonadal function in the diabetic child. Pediatr Res 12, 157 (1978). https://doi.org/10.1203/00006450-197802000-00066
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DOI: https://doi.org/10.1203/00006450-197802000-00066
