Abstract
Summary: CDP-choline: 1,2-diglyceride choline phosphotransferase (CPT; EC 2.7.8.2) undergoes a marked surge in activity in human amniotic fluid when assayed from 30 weeks of gestation to term. The activity of this enzyme, plotted against gestational age, follows a highly significant regression correlation from which an equation can be obtained for the prediction of gestational age.
Speculation: In addition to its potential use in obstetrics, it is possible that a rapid and inexpensive assay for CPT or phosphatidic acid phos-phohydrolase could be applied to pharyngeal or gastric secretions in neonates. These assays could be used to differentiate between pulmonary surfactant deficiency states and other pulmonary and cardiac disease states.
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Sass, N., Killam, A., Rounsavill, M. et al. Assessment of Third Trimester Choline Phosphotransferase Activity in Uncomplicated Human Pregnancies. Pediatr Res 12, 729–730 (1978). https://doi.org/10.1203/00006450-197806000-00011
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DOI: https://doi.org/10.1203/00006450-197806000-00011
