Abstract
Binding capacity of TeBG was measured in 8 cord bloods, and in the peripheral venous blood of 39 male and 31 female infants aged 1 day to 1 year. In cord blood, TeBG levels were low (1.27 ± 0.3 μg%). In male infants, TeBG levels increased from birth to 3 months, before decreasing to reach the prepubertal level at 6 months. Individual values ranged between 1.16 and 14,5 μg% and were significantly correlated with plasma testosterone (p < 0.001) and estradiol (p < 0.01) levels, in female infants, individual values ranged between 1.17 and 14.5 μg%, without correlation with age or plasma estradiol level. In male infants the data suggest a positive control of TeBG binding capacity by estrogens, the negative effect of testosterone being delayed until after the 3d month of age. In girls, the lack of correlation between TeBG and estradiol can probably be explained by instability of plasma estradiol levels.
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Chaussain, J., Brijwai, A., Roger, M. et al. Serum Testosterone estradiol Binding Globulin (TeBG) binding capacity during the first year of life. Pediatr Res 12, 157 (1978). https://doi.org/10.1203/00006450-197802000-00067
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DOI: https://doi.org/10.1203/00006450-197802000-00067
