Abstract
The pituitary gonadotrophin response to a single intravenous dose of 25 μg LH-RH was studied in 43 boys being investigated for delayed puberty. Two different patterns evolved during 6-24 months follow up. A minority (13/43) showed no further genital development and were observed to have hypogonadotrophic hypogonadism. These patients had previously shown similar gonadotrophic responses to those of prepubertal controls : the ratios LH/FSH integrated responses were less than 1. The majority (30/43) spontaneously entered puberty and was thus regarded as having constitutional delayed puberty. The retrospective analysis of their gonadotrophin responses showed ratios LH/FSH integrated responses higher than 1. These results were similar to those of pubertal controls and thus notconsistant with their clinical immaturity concomitant to the test. The existence in such patients of pubertal pattern of pituitary response to LH-RH before clinical onset of puberty is a useful prognostic index.
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Ernould, C., Bourguignon, J., Franchimont, P. et al. Prognostic value of LH-RH test in boys with delayed puberty. Pediatr Res 12, 157 (1978). https://doi.org/10.1203/00006450-197802000-00070
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DOI: https://doi.org/10.1203/00006450-197802000-00070
