Abstract
Serum concentrations of testosterone(T), Δ4-androstenedione(A), dehydroepiandrosterone(DHEA) and its sulfate(DS), estradiol(E2), cortisol(F), and CA vere measured by radloimmunoassays repeatedly in 11 girls with PP, treated vith 81-136 mg/M2/d of CA for 2-60 ttonths(Tatle indicates ranges).
Hormones were also determined 30' after 0.25mg of tetracosactid i.v.DHEA and A increased in 7/11 and 8/11, T in 2/11, DS in none. There vas no relation to the response of F(normal in 4, subnormal in 3, absent in 4)or to the CA levels. Thus high-dose CA treatment suppressed E2 and adrenal steroids, T remained elevated in half of the girls with high CA concentrations. possibly related to its anti-androgen effect.
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Korth-Schutz, S., Schwartz, D., Muehlendahl, KE. et al. Adrenal and Ovarian Steroids versus Cyproterone Acetate(CA) in Girls with Precocious Puberty(PP). Pediatr Res 12, 158 (1978). https://doi.org/10.1203/00006450-197802000-00076
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DOI: https://doi.org/10.1203/00006450-197802000-00076
