Abstract
Saliva is an alternative fluid for steroid analyses in children. Sensitive RIAs have been developed for cortisol(F), 170H-progesterone(17P) and progesterone (P) in parotid fluid and mixed saliva. Pre and post-TLC saliva values correlated for each steroid. A saliva F diurnal rhythm was seen in normals but not in Cushing's syndrome. Synacthen caused a rise in saliva F in normals but not in Addison's disease. CAH patients showed a correlation between plasma and saliva 17P levels (r=0.90). Saliva P levels increased on day 14 in 4 normal menstrual cycles, peaking 8 days later. Results indicate a practical role for saliva steroid measurements in paediatric endocrine disorders. Furthermore, the non-protein bound nature of steroids in saliva more accurately reflects plasma free steroid levels.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hughes, I., Walker, R. & Riadfahmy, D. Saliva steroid measurement in childhood. Pediatr Res 12, 1084 (1978). https://doi.org/10.1203/00006450-197811000-00016
Issue date:
DOI: https://doi.org/10.1203/00006450-197811000-00016
