Abstract
In hypopituitary Snellmice, we studied the effects of hGH, insulin and peptide fractions containing SM-activity(SM-P) and insulin-like activity as measured by radioreceptorassay (RRA), but no L-thyroxine,prolactin,testosterone,insulin and GH,on body length,weight,cartilagemetabolism and serum glucose(SG). Cartilage activity (CA) was estimated by 21 hrs incubation in medium with 35S-sulfate. Treatment for 4 weeks with saline, hGH and SM-P induced an increase(as % of initial value ± SEM) in length of resp.104 ± 1.0, 113.8 ± 1.3 and 109.8 ± 1.3%, and in weight of 114.6 ± 3.3 135.4 ± 5.3, 132.8 ± 1.5%. Insulin, at a dose equal to the insulin-like activity of SM-P in RRA units had no effect on length and weight. After three days of treatment CA is resp.1672 ± 223; 5088 ± 444; 4225 ± 163 dpm/mg dry cartilage; Insulin induced a decrease of SG. SM-P had an equal effect at the same dose level in RRA-units, hGH had no effect.
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Van Buul, S., Van Den Brande, J., Dumoleijn, L. et al. Growth of Snell dwarfmice with hGH, insulin and peptide fractions containing SM-activity. Pediatr Res 12, 1087 (1978). https://doi.org/10.1203/00006450-197811000-00036
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DOI: https://doi.org/10.1203/00006450-197811000-00036
