Abstract
Hypophysectomy of rats on the 14th day of pregnancy is not associated with the expected fall of serum somatomedin until after delivery. RCS was measured by radioreceptor assay utilizing membranes prepared from pregnant rabbit mammary gland and I125I] oPRL. As compared to normal pregnant rats we found that serum PRL-RRA (ng/ml) of sera from hypox pregnant rats was higher than that of normal pregnant rats at 16 days 575 ± 83 (n=5) vs 201 ± 70 (n=5) p<.01 GH 18 and 20 days (1585 ± 234 (n=5) vs 786 ± 120 (n=3) p=.05. Serum GH-RRA measured by pregnant rabbit liver membrane was also higher in hypox than normal pregnant rat. Placental content of rCS was not altered by hypophysectomy. PRL/GH RRA of rCS was about 18.
We conclude that serum somatomammotropin is maintained at higher than normal concentration after hypophysectomy of pregnant rats. We suggest that this peptide maintains somatomedin production in hypox pregnant rats.
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Daughaday, W., Trevidi, B. & Kapadia, M. Increased concentrations of chorionic somatomammotropin (rCS) serum of hypophysectomized pregnant rats. Pediatr Res 12, 1087 (1978). https://doi.org/10.1203/00006450-197811000-00037
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DOI: https://doi.org/10.1203/00006450-197811000-00037
