Abstract
Gonadotrophin releasing hormone (LHRH, Hoechst) 500 μg has been administered subcutaneously twice daily to four patients (two male, two females) with hypogonadotrophic hypogonadism due to LHRH deficiency for a minimum of one year. The initial results were extremely encouraging in terms of the biochemical responses and physical changes but in all four patients gonadotrophin responsiveness waned, levels of sex steroids were not maintained and pubertal development failed to progress.
The diminishing responsiveness of the pituitary to continual stimulation with LHRH appears severely to limit the use of LHRH as a therapeutic agent, although it is possible that smaller doses given more intermittently may be effective. Theoretical considerations and experimental data obtained in dogs suggest that this may be the case.
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Brook, C. Long-term treatment with high dose gonadotrophin releasing hormone to induce puberty. Pediatr Res 12, 1098 (1978). https://doi.org/10.1203/00006450-197811000-00101
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DOI: https://doi.org/10.1203/00006450-197811000-00101
