Abstract
Increased levels of GHb (HbA1a-c) serve as an indicator of the degree of hyperglycemia over the life span of the erythrocyte. Blood GHb was measured in 29 normal (N) and 50 diabetic children and adolescents (D) in the postprandial state. GHb was determined by cation exchange chromatography with “Isolab” columns. In the N subjects mean GHb was 7.7±1.1% of total HbA (Range: 6.0–9.5%). In the D patients the range was 7.7–20.1%. A significant negative linear correlation (r=0.68 p < .001) was found between GHb and urine glucose excretion measured 3 times daily for 3 months. Significant differences in GHb were also found when the patients were grouped according to the frequency distribution of the daily urine glucose excretion; GR 1: 0-½% - GHb=9.9±1.8%; GR 2: 1–2% - GHb=12.2±0.9%; GR 3: 2–4% - GHb=14.0±1.9%; GR 4: > 5% - GHb=16.7±1.8% (p < 0.01 - 0.001). A significant curvilinear relationship was found between GHb and postprandial blood glucose levels (y=a+b In(x) r=0.6 p < .001) suggesting that GHb reflects a saturable system of glycosylation. Concentration of GHb serves as a useful index for diabetes control.
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Karp, M., Topper, E., Doron, M. et al. Glycosylated Hemoglobin (GHb) as an index of diabetes control in diabetic children and adolescents. Pediatr Res 12, 1098 (1978). https://doi.org/10.1203/00006450-197811000-00103
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DOI: https://doi.org/10.1203/00006450-197811000-00103
