Abstract
Summary: An intestinal perfusion technique has been used to study absorption of glucose from free glucose and the disaccharide maltose in a patient with congenital glucose-galactose malabsorption.
Minimal absorption of glucose occurred from high luminal concentrations of either free glucose (100 mmole/liter) or maltose (50 mmole/liter). Glucose diffused into the intestinal lumen during perfusion of a 2 mmole/liter glucose solution.
These observations offer no support for nutritionally important glucose absorption in congenital glucose-galactose malabsorption by either passive diffusion or via a “disaccharidase-related” transport system.
Speculation: In patients with congenital glucose-galactose malabsorption a disaccharidase-related transport system is of no importance as a physiologic mechanism in compensating for the primary defect of monosaccharide absorption.
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Fairclough, P., Clark, M., Dawson, A. et al. Absorption of Glucose and Maltose in Congenital Glucose-Galactose Malabsorption. Pediatr Res 12, 1112–1114 (1978). https://doi.org/10.1203/00006450-197812000-00002
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DOI: https://doi.org/10.1203/00006450-197812000-00002
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