Abstract
Iodine deficieny in adults causes preferred synthesis of triiodothyronine(T3)an observation not having been reported in newborns with this condition. After starting a local program for screening of congenital hypothyroidism neonatal iodine-deficient goiter with hypothyroidism was observed in a frequency of 1.2 per cent.Mean total thyroxine(T4)in 8 goitrous newborns was 6.2 ± 1.45 μg/100 ml(+SD)compared to 15.5+2.9 μg/100ml In normalweight fullterm newborns at 4 days of life. Mean total T3 in iodine-deficient newborns was 2.59±0.65 ng/ml compared to 1.5 ng/ml in normal newborns of the same age. Serum thyrotropin (TSH) remained elevated during the second half of the first week in iodine-deficient newborns. Percutaneous application of iodine resulted in a quick disappearance of goiter and normalization of T4 and tsh within a few days. T3 returned to normal more slowly within days or weeks. General iodine prophylaxis is needed in Germany.
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Stubbe, P., Heidemann, P. Iodine-deficient goiter in newborns during the course of neonatal screening. Pediatr Res 12, 160 (1978). https://doi.org/10.1203/00006450-197802000-00088
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DOI: https://doi.org/10.1203/00006450-197802000-00088
