Abstract
In 12 hypo- and 32 euthyroid children the distribution of urinary steroids on the fractions of free steroids(F), glucuronides(G), and sulfates(S) was studied. F, G, and S were separated on SEPHADEX LH-20 before cleavage of conjugates, steroids determined by capillary-GLC. Although G remained the main fraction in hypothyroidism the percentage of S and F was about twice as high as in euthyroid patients. especially after ACTH-stimulation. Apparently the decrease in glucuronyltransferase activity was more pronounced than that in the sulfotransferase system, a situation like in newborns, indicating retarded development rather, than, temporarilly reduced activity in hypothyroidism. The fact that it took more than 4 weeks after start of therapy with thyroid hormone for the %-distribution of steroids to equal that of healthy children supports this contention.
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Wiebel, J. Decreased Steroid Glucuronyl Transferase Activity in Hypothyroidism of Children Aged 1–6 Years. Pediatr Res 12, 161 (1978). https://doi.org/10.1203/00006450-197802000-00091
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DOI: https://doi.org/10.1203/00006450-197802000-00091
