Abstract
From 47 diabetic children 19 had a urinary calcium excretion 2 S.D. above the mean of 58 healthy children. In 13 of these 19 children the hypercalciuria persisted on follow-up and was independent of the glucose excretion. The hypercalciuric group compared to the normocalciuric diabetic group had a significantly higher pH and calcium/creatinine ratio in fasting urine samples, whereas the blood pH, bicarbonate, glucose and the serum calcium, ionised calcium, phosphate, alkaline phosphatase, iPTH, hCT, hGH levels were not different. In the hypercalciuric group an oral calcium load increased the TmP/GFR but not the urinary calcium/creatinine ratio and decreased the urinary cAMP excretion. Indomethacin lowered the calcium/creatinine ratio in fasting urine samples of the hypercalciuric, but not of the normocalciuric group without changing the sodium excretion.
It is suggested that prostaglandins contribute to a defective renal tubular function, causing hypercalciuria.
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Drayer, N., van Damme-Lombaerts, R., Rouwe, C. et al. Hypercalciuria of renal origin in diabetic children: incidence and response to indomethacin. Pediatr Res 12, 162 (1978). https://doi.org/10.1203/00006450-197802000-00097
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DOI: https://doi.org/10.1203/00006450-197802000-00097
