Abstract
Serum TeBG binding capacity was measured by polyacrylamide gel electrophoresis in 4 groups of obese subjects with weight excess ranging between 30 and 120% (20 prepubertal and 13 pubertal boys, 12 prepubertal and 11 pubertal girls). In prepubertal obese children, values were identical in boys (2.52 ± 1.04 μg%) and girls (2.65 ± 0.74μg%), but significantly lower (p<0.01) than in controls and negatively correlated to the percentage of obesity (R = 0.51, p<0.01). At puberty, TeBG values remained unmodified in obese girls (2.17 ± 0.72 μg%) but decreased significantly (p<0.01) in males (1.39 ± 0.49 μg%). In obese subjects plasma testosterone and estradiol were normal while plasma DHA was elevated and, in girls, correlated negatively with TeBG (R = 0.66, p<0.01). The data suggest that TeBG is decreased in obesity independently of gonadal steroids levels but a relationship may be speculated with an increased production of adrenal androgens.
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Georges, P., Chaussain, J., Brijawi, A. et al. Binding capacity of serum Testosterone estradiol Binding Globulin (TeBG) in obese children. Pediatr Res 12, 162 (1978). https://doi.org/10.1203/00006450-197802000-00098
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DOI: https://doi.org/10.1203/00006450-197802000-00098
