Abstract
Six boys with CD ranging in age from 14 5/12 to 16 2/12 yrs. were evaluated with measurements of 24 hr. integrated concentrations (IC) of LH, T, and androstenedione (Δ), the LH and FSH response to LH-RH, and growth hormone (GH) concentration following arginine-insulin (AITT). Each boy was treated with 3 monthly injections of 200 mg T enanthate and the same studies were repeated 2 months after the last injection of T.
The mean growth rate was 3.75 cm/5 mo. and there was no significant increase in bone age. All boys had a progression in sexual development to Tanner Stage II or III with appropriate increase in testicular volume. Following T therapy, all boys had significant increase (p < .01) in the IC of LH, testosterone and Δ, especially the nocturnal IC LH. There was no significant difference in the IC GH. After T therapy, all boys had significantly increased concentrations of LH and FSH following LH-RH (p < .01). There was no significant difference in GH concentrations during AITT following T therapy.
In the 8 months following T therapy, 5 of 6 boys have continued their pubertal maturation and increased statural growth with appropriate skeletal maturation. One boy has not had the expected pubertal progression. Further longitudinal studies are needed but small doses of T may be safe and beneficial in the treatment of CD.
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Gutai, J., Postellon, D., Kenien, A. et al. 6 TESTOOSTERONE (T) THERAPY FOR BOYS WITH CONSTITUTIONAL DELAY OF PYBERTY (CD). Pediatr Res 12 (Suppl 4), 364 (1978). https://doi.org/10.1203/00006450-197804001-00011
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DOI: https://doi.org/10.1203/00006450-197804001-00011
