Abstract
Titers of “natural” antibodies to E.Coli O antigens of different serotypes (01.K1.H7; 02.K1.H4; 04.K3.H5; 06.K2 ac H1; 015.K14.H4; 075.K?.H5) and to rabbit red blood cells (RaRBC) were determined in 82 subjects with Down's syndrome (DS) and 76 mentally retarded but chromosomally normal controls. Age ranged from 1 to 50 years; subjects with DS and controls were matched for sex, age and socio-environmental conditions. Titera of both antibodies assessed by hemagglutination, were significantly lower in subjects with DS 1 to 5 years old. E. Coli antibodies transiently increased to normal values in subjects with DS during the second 5 years of life, thereafter rapidly declining to levels significantly lower than those observed in controls. The RaRBC antibody titer in subjects with DS remained significantly lower up to the age of 15; due to the rapid age-dependent decline of RaRBC antibody titera in controls, the significance of the difference between the 2 groups disappeared at later ages. These data can be taken as further evidence for the existence of a congenital imnunodeficiency in DS.
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Burgio, G., Lanzavecchia, A., Plebani, S. et al. IMMUNODEFICIENCY IN DOWN'S SYNDROME. AHTIBODIES TO E.COLI AND RABBIT ERYTHROCYTES AT DIFFERENT AGES. Pediatr Res 12, 64 (1978). https://doi.org/10.1203/00006450-197801000-00025
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DOI: https://doi.org/10.1203/00006450-197801000-00025
