Abstract
The role of the cardiovascular regulatory system in controlling renal circulation was assessed by renal responses to stimulation of vasoactive sites within the central nervous system. Piglets aged 1-25 days were anesthetized with 0.25-0.5% halothane in N20-02, paralyzed, ventilated to maintain normal arterial blood gases and pH and placed in a stereotaxic apparatus. Stimuli (0.1msec pulses, 0.1-1.0mA, 1-100Hz) were delivered through enamel-coated nichrome wire (0.3mm tip diameter). Renal arterial flow (RF) was recorded continuously (electromagnetic transducers) with aortic pressure (AoP) and heart rate (HR). Resistance (R) was calculated as mean AoP/mean flow. In 7 piglets less than one week old, medullary pressor point area stimulation (≥ increase without HR change) significantly increased RF without consistently changing R. Lateral hypothalamic stimulation by high frequencies significantly increased both ≥ and R in 10 piglets of all ages. Active renal circulatory responses (R changes) to lateral hypothalamic stimulation were obtained at an earlier age than to medullary stimulation. (Supported by Nassau Heart Assoc.)
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Gootman, P., Gootman, N. & Buckley, B. 114 RENAL CIRCULATORY EFFECTS OF DIRECT STIMULATION OF CENTRAL AUTONOMIC NERVOUS SYSTEM IN PIGLETS. Pediatr Res 12 (Suppl 4), 382 (1978). https://doi.org/10.1203/00006450-197804001-00119
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DOI: https://doi.org/10.1203/00006450-197804001-00119
