Abstract
The association of DM,HT and JRA has not been previously recorded.The purpose of this communication is to report our preliminary findings in a 14 year old Haitian girl who developed insul in- dependent DM at age 6 yrs, goiter at 9 yrs, and polyarticular JRA at 12 yrs.No evidence of iridocyclitis was present.Following thyroid and gold therapy the goiter regressed and the arthritis improved.There was a family history of DM and goiter in the mother and of DM in maternal relatives.Investigations revealed normal T4;antimicrosomal thyroid antibodies (1:25,000 and 1:7,000);antinuclear antibodies (1:32,768 and 1:1,024);rheumatoid factor (1:320 and 1:640);high-normal C3 (240mg%) and elevated C4 (240mg%);normal IgA and IgM,elevated IgG;elevated gamma globulin; normal CBC peripheral smear and serum B12;normal adrenal response to ACTH stimulation;HL-A,A-28,A-9,B-27,B-7,CW-2;elevated ESR (33 and 26 mm/hr); and evidence of JRA on wrist x-ray.These findings are consistent with the presence of an autoimmune disorder. Furthermore,their association with DM in this patient lends support to the concept that DM may itself be a disease of autoimmune origin.We believe this to be the first report of the coexistence and concurrent expression of DM, HT and JRA in one individual.
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Fisher, M., Abrams, C. & Aballl, A. 296 DIABETES MELLITUS (DM), HASHIMOTO'S THYROIDITIS (HT)AND JUVENILE RHEUMATOID ARTHRITIS (JRA) IN A 14-YEAR-OLD GIRL. Pediatr Res 12 (Suppl 4), 413 (1978). https://doi.org/10.1203/00006450-197804001-00301
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DOI: https://doi.org/10.1203/00006450-197804001-00301
