Abstract
Sixteen 47,XXY boys have been followed prospectively from birth and are being recalled for endocrine studies. To date 6 boys (6yr-13yr) have been studied and available results are presented. LHRH stimulation test (10μg/Kg IV bolus) and HCG stimulation (2,000 IV 1M X 3 days) were given and analyzed for LH, FSH, test-osterone & estradiol.
We interpret these data to indicate 1) normal pituitary function, 2) the elevated estradiol, which is associated with hypergonado-trophic hypogonadism in 47,XXY adults with Klinefelter's syndrome starts to manifest itself before puberty and may be an early indication of later hypogonadism.
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Hudson, M., Winter, J. & Robinson, A. 304 HORMONE STUDIES IN PREADOLESCENT 47, XXY BOYS. Pediatr Res 12 (Suppl 4), 414 (1978). https://doi.org/10.1203/00006450-197804001-00309
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DOI: https://doi.org/10.1203/00006450-197804001-00309
