Abstract
A critical phase in the structural and functional maturation of the pancreas takes place in the neonatal period. The response to Reo Virus type 3 in suckling mice was studied after injecting 1×107 PFM into 9 day old animals intraperitoneally. Both control and test animals were sacrificed either 3 or 6 days following viral injection. Histology of the pancreas, after 3 and 6 days of viral infection, revealed a normal architecture, normal acinar cells with only a mild mononuclear infiltration observed in mice after 6 days of infection (F).
In the 6 day infected mice, amylase (A), is significantly reduced (p< 0.001) as compared to the control of the same age. Lipase (L) is decreased as well, but to a lesser degree. In contrast, trypsin (T), increased significantly (p<0.02) in 3 day infected, but no difference in activity is seen in 6 day infected mice. Chymotrypsin (CT), was increased significantly (p < 0.02) over the similar control group. Carboxypeptidase A (CPA) & B (CPB) activities were not altered in either the 3 or 6 day infected animals. The enzyme activities can be divided into three groups; the amylase and lipase activities are diminished, the endopeptidases, trypsin and chymotrypsin are increased and the exopeptidases, carboxypeptidase A & B are without change. The effect of the viral infection on the enzyme activities indicate a non-parallel change on the developmental pattern of the pancreatic enzymes. (*units ± S.D. = μ moles/mg protein/min.)
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Branski, D., Faden, H., Hatch, T. et al. 400 A NON-PARALLEL DECREASE IN PANCREATIC ENZYMES IN REO VlRUS TYPE 3 INFECTION OF SUCKLING MICE. Pediatr Res 12 (Suppl 4), 430 (1978). https://doi.org/10.1203/00006450-197804001-00405
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DOI: https://doi.org/10.1203/00006450-197804001-00405
