Abstract
In acute urinary tract infections of children we previously found that 1. lymphocyte responsiveness to T-cell mitogens is suppressed at the acute stage of infection, 2. the suppression is more pronounced in pyelonephritis than in lower urinary tract infections (LUTI), and 3. upon recovery there usually is a return to normal responsiveness. The suppression of cell-mediated immunity could result from a preceding viral infection. In a material consisting of 53 cases of pyelonephritis and 39 LUTI studiad by sequential serum specimens a concomitant virus infection was diagnosed in 7 cases (7,6%). The following viruses were detected: parainfluenza type 3 (3 cases), rotavirus (2), respiratory syncytial virus (2). It is concluded that viral infections in most cases are not responsible for the decreased lymphocyte responsiveness in pyelonephritis and LUTI, but the immunosuppression is associated with the bacterial infection per se. On the other hand, in some cases certain viruses may have a role in the pathogenesis of urinary tract infection.
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Vesikari, T., Janas, M. & Anttila, R. Viral infections associated with acute urinary tract infections in children. Pediatr Res 13, 87 (1979). https://doi.org/10.1203/00006450-197901000-00105
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DOI: https://doi.org/10.1203/00006450-197901000-00105
