Abstract
In 20 years we gathered 239 acute myeloblastic leukemias (AML), 26 promyelocytic (APLM) and 35 monoblastic (AMoL). During the same period 1300 acute lymphoid leukemias (ALL) were treated. The peak of frequency between 3 and 3 noticed in ALL is absent in granulocytic loukemias. AML. The remission rate is 54 % (33 % in adults). The higher the WBC, the worse the results. With recent protocols combining daunomycin (DNR) and aracytine the rate reaches 75 % (48 % in protocols without DNR). The survival curve in similar in adults and children with a median of 7 months. Survival is shortened by a high initial WBC or a large splenomegaly. Only 3 % of the patients are alive after 4 years. First relapse occurs mostly in bone marrow, unusually isolated in meninges (7 %). A second short remission is possible in 43 % of the cases. APML. With protocols using DNR and heparin the remission rate is 75 % with a median survival of 16 months. There is no meningeal relapses.AMoL. The remission rate is 77 % with rubidazone, 21 % without. The median survival is 6 months and the frequency of initial or secondary meningeal involvement justifies cranial X ray prevention.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schainon, G., Jacquillat, C., Weil, M. et al. 22 300 CASES OF ACUTE GRANULOCYTE LEUKEMIA IN CHILDREN. Pediatr Res 13, 951 (1979). https://doi.org/10.1203/00006450-197908000-00038
Issue date:
DOI: https://doi.org/10.1203/00006450-197908000-00038
