Abstract
A total of 55 doses of THF (1.5 mg/kg/day) was given to a 5.5 month old male with Di George Syndrome.Skin tests (for PHA and Candida) were negative,E rosettes were low (24%),blastogenic transformation response to PHA and allogeneic lymphocytes were low prior to therapy. He had a low level of circulating thymic factor (5.0 pmoles/107 cells) and a marginal stimulation of target cells. E rosettes showed a 59 percent increase after incubation (in vitro) with THF. No side effects of THF was observed. Despite a clinical well being and weight gain,episodes of gastroenteritis and otitis continued. After THF treatment (at age of 10 months) percentage of E rosettes (56%) and in vitro lymphocyte response to PHA were increased; skin test for PHA became positive. But no improvement in in vitro response to candida and allogeneic lymphocytes was observed.
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Ersoy, F., Sanal, Ö., Yegin, O. et al. 44 THYMIC HUMORAL FACTOR (THF) THERAPY IN A PATIENT WITH DI GEORGE SYNDROME. Pediatr Res 13, 955 (1979). https://doi.org/10.1203/00006450-197908000-00060
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DOI: https://doi.org/10.1203/00006450-197908000-00060
