Abstract
Disturbances in carbohydrate metabolism, lipid pattern and platelet function are potential risk factors in the development of vascular complications in juvenile diabetics. In a prospective study including 29 diabetic children the relationship between these factors has been studied. Carbohydrate control was measured by HbA1, by Clinitest analysis of three urine portions a day, three days a week for two months, and by clinical judgement. Platelet function was studied by Born aggregometry.
Results: The relative number of positive Clinitest results was highly correlated to HbAl (r=0.83). There was a complete accordance between clinical judgement and HbA1. A positive correlation was also found between HbAl and serum triglycerides (r=0.61). The platelets from poorly controlled children often lacked shape change and showed slower aggregation velocity and less pronounced maximal aggregation.
Summary: HbA1 is a very good indicator of carbohydrate control. Serum triglycerides and platelet aggregation are affected by the degree of diabetic control.
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Tuvemo, T., Ewald, U. & Wålinder, O. Does good diabetic control influence serum lipids or platelet function in diabetic children?. Pediatr Res 13, 1197 (1979). https://doi.org/10.1203/00006450-197910000-00104
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DOI: https://doi.org/10.1203/00006450-197910000-00104
