Abstract
Previous data have suggested an age related increase in renal tubular secretion of digoxin in infants and children receiving long term digoxin therapy. This phenomenon could be the result of a maturational process or secondary to chronic substrate stimulation. To investigate this question two groups of 2 week old paired litter-mate rats received intraperitoneal injections of either digoxin or an equal volume of normal seline (control) an alternate days until sacrificed at 4, 6, and 8 weeks of age. An additional group of 12 week old rats were studied as controls. I125 digoxin uptake was measured in renal cortical slices as the CPM/mg wet tissue slice to medium ratio (S/M). Both digoxin treated and control rats demonstrated significant age related increment in digoxin uptake. S/M ratios at 4, 6, 8, and 12 weeks in the control group were (mean ± S.D) 1.34 ± 0.06, 1.39 ± 0.14, 1.62 ± 0.18 and 1.93 ± 0.25 respectively (r = 0.81, p < 0.001) but did not differ significantly at each age from those in the control group. I125 uptake was significantly reduced by both Dinitrophenol (DNP) and sodium azide, as well as by a 100% nitrogen atmosphere.
These results indicate that renal tubular transport of digoxin is an age related energy dependent process, which probably is not subject to substrate stimulation.
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Aladjem, M., Kaplinsky, C., Laufer, Y. et al. MATURATION OF RENAL TUBULAR TRANSPORT OF DIGOXIN. Pediatr Res 14, 986 (1980). https://doi.org/10.1203/00006450-198008000-00079
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DOI: https://doi.org/10.1203/00006450-198008000-00079
