Abstract
The developmental pattern of regional glomerular density (GD) and glomerular perfusion rate (GPR) was studied in 29 fetal kidneys between 103-142 days of gestation (term 145 days) and in 8 newborn kidneys (3 to 19 days) using 15μ microspheres. The relative distribution of GD, measured in four cortical zones (zone 1 being the most outer portion) decreased in zone 1 from 44±3% in fetuses <120 days to 31±1.5% in newborns (p<0.01) and increased from 17±1.5% to 25±1.2% in zone 3 (p<0.05). No significant changes were seen in GD in zones 2 or 4. GPR values (nl/min), computed for each cortical zone, did not increase during fetal life (see Table). However, after birth, GPR increased three times in zones 1 and 2, doubled in zone 3 and did not change in zone 4 when compared to mean fetal GPR values.
The increase in GPR in zones 1 and 2 followed the increase in glomerular filtration rate (GFR) very closely (r=0.82 and 0.86) in newborns. The present results suggest that the rapid increase in GFR following birth may depend on the increase in GPR in the outer portion of the cortex.
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Robillard, J., Weiamann, D. & Smith, F. DEVELOPMENT OF GLOMERULAR PERFUSION RATE (GPR) IN FETAL AND NEWBORN LAMBS. Pediatr Res 14, 987 (1980). https://doi.org/10.1203/00006450-198008000-00085
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DOI: https://doi.org/10.1203/00006450-198008000-00085
