Abstract
The aim of this study was to establish normal values for urinary excretion of prostaglandins (PG) E2 and F2α and of kallikrein(KALL) at different ages of development, and to correlate them with several parameters of renal function. In 55 healthy infants and children of both sexes, aged 2 days to 14 years, daily urinary PGE2 and PGF2α were determined by specific radioimmunoassays; KALL was measured by an enzymatic method. Results (mean ± SEM):
In contrast to the activity of the renin-angiotensin-aldosterone system, which is known to decrease from birth on, urinary PGE2, PGF2α and KALL significantly increased with age. These changes were not correlated to blood pressure, UV, UNa+, Uosm or GPH, and were obliterated when results were corrected for surface area.
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Godard, C., Dale, B., Vallotton, M. et al. URINARY PROSTAGLANDINS AND KALLIKREIN IN HEALTHY CHILDEEN FROM BIRTH TO ADOLESCENCE. Pediatr Res 14, 988 (1980). https://doi.org/10.1203/00006450-198008000-00091
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DOI: https://doi.org/10.1203/00006450-198008000-00091
