Abstract
This study was undertaken to examine the degree of renal (R) functional and structural (S) involvement in STZ-Insulin (I) dependent (STZI, for 3-8 years; I requirement 2-7 U/day) or STZ carbohydrate disturbed (CHO, for 3-9 years) or Px (for 2-4 years; I, 2-7 U/day) model of diabetes (D) in RM. Glomerular filtration rate (GFR) renal plasma flow (RPF) urinary protein (UP) and kidney biopsy (BX) were done. Bx was evaluated by light microscopy (LM). In STZI and Px blood sugar ranged between 150-400mg%.
GFR and RPF was significantly low in CHO and normal in STZI compared to C. GFR and RPF was high in Px compared to C but not significant. There was significant proteinuria (P) in CHO, STZI, and Px. In 4/5 STZI and 3/5 Px LM change consisted of basement membrane thickening and increase in mesangial matrix. LM changes and P in STZI and Px suggest D nephropathy. This study also suggests that structural changes (SC) can precede R dysfunction e.g. STZ and Px or vice-versa e.g. CHO. Early I therapy did not prevent SC in STZ or Px, most probably due to inadequate D control. *P< .05.
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John, E., Manaligod, J., Miller, J. et al. CHANGES IN RENAL FUNCTION AND MORPHOLOGY IN STREPTOZOTOCIN (STZ) AND PANCREATECTOMIZED (PX) RHESUS MONKEYS (RM). Pediatr Res 14, 990 (1980). https://doi.org/10.1203/00006450-198008000-00100
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DOI: https://doi.org/10.1203/00006450-198008000-00100
