Abstract
We have studied 2 patients in whom glomerular injury was associated with M. pneumoniae infection. Case 1 (Nephron 21:284, 1978), an 11 y. girl, had pneumonia, pleural effusion and hematuria. Case 2, a 13 y. boy, had gross hematuria and diffuse pneumonitis. BUN and serum creatinine concentrations were normal in Case 1 and slightly elevated in Case 2 (30 and 1.1 mg/d1). ASOT, throat culture and C3 were normal or negative in both.
Evidence for M. pneumoniae infection was:
In Case 1 the renal biopsy revealed an acute glomerulonephritis, IgG, C3 and mycoplasma antigen along glomerular capillary loops and in the mesangium.
In Case 2 the biopsy revealed a focal glomerulonephritis. IgA, C3 and weak fluorescence for mycoplasma antigen were seen in the mesangium.
We conclude that M. pneumoniae may be associated with an immune complex glomerulonephritis as well as an IgA nephropathy (Berger's disease).
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Kaplan, B., Hutcheon, R. GLOMERULAR INJURY ASSOCIATED WITH MYCOPLASMA PNEUMO- NIAE INFECTION. Pediatr Res 14, 996 (1980). https://doi.org/10.1203/00006450-198008000-00139
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DOI: https://doi.org/10.1203/00006450-198008000-00139
