Abstract
The etiology and pathogenesis of minimal lesion nephrosis (MLN) is uncertain. An abnormality of the regulatory function of T cells has been suggested to account for the decreased levels of IgG and increased levels of IgM. To learn more of the function of the immune system on these patients, 26 children with MLN and 12 children with renal disease other than MLN were immunized with dilute typhoid vaccine and the humoral antibody response to both protein (H or flagellar antigen) and polysaccharide (O or somatic) antigens was determined. The antibodies against H and O antigens were determined by quantitative agglutination test. Additionally, the O antibody titers were quantitated by the passive hemagglutination test. None of the 26 patients with MLN produced antibodies in titers of 320 or above against the H antigen, in contrast to 50% of the control subjects. The difference is statistically highly significant at a value of p<0.01. No such differences were noted in the antibody responses to polysaccharide O antigen. Determination of the immunoclass by means of 2-mercaptoethanol reduction indicates that the major portion of both H and O antibodies was of the IgM class. Therefore, it may be concluded that patients with MLN responded less well than control subjects to the typhoid protein H antigen but equally well to corresponding O antigen of S. typhi. These observations support the assumption of an immunologic abnormality of the disease.
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Baliah, T., Gamboa, L. & Neter, E. THE IMMUNE RESPONSE TO TYPHOID VACCINE OF PATIENTS WITH IDIOPATHIC MINIMAL LESION NEPHROSIS. Pediatr Res 14, 999 (1980). https://doi.org/10.1203/00006450-198008000-00156
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DOI: https://doi.org/10.1203/00006450-198008000-00156
