Abstract
Two pediatric patients with shunt nephritis, one infected by Micrococcus (M), and the other by Staph. albus (S), were studied. Both exhibited cryoglobulinemia, elevated IgG indicating chronic infection, and very high agglutinating antibody titers (1:4000) against the respective organisms (M and S) cultured from the patients' blood. After revision of the shunts, the half life of the specific antibodies was determined.
Renal biopsies disclosed membranoproliferative glomerulonephritis type I (M) and type III (S). Granular deposits containing Clq, C3, IgM and IgG were detected at immunofluorescence examination. The glomerular immune deposits are currently being investigated for the presence of micrococcal and staphylococcal antigens.
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Leumann, E., Briner, J., Joller, P. et al. IMMUNOLOGIC STUDIES IN SHUNT NEPHRITIS CAUSED BY MTCROCOCCUS AND STAPH. ALBUS INFECTION. Pediatr Res 14, 1013 (1980). https://doi.org/10.1203/00006450-198008000-00239
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DOI: https://doi.org/10.1203/00006450-198008000-00239
