Abstract
It was previously reported by us that, in animals infected with herpes simplex virus type I in a 4-10 day acute experiment, virus antigen and antibodies could be detected in the glomeruli.
In the present chronic experiment, 11 New Zealand rabbits were infected i.v. with herpes simplex virus type I for 8 weeks. 10 animals served as controls.After 8 weeks, kidney,brain,blood and urine examinations were performed. The quantity of soluble immune complex value was measured in 6 of the 11 animals, and a moderately pathologic value in 3. In 9 rabbits virus antigen and granular IgG were detected on the glomerular basal membrane, and lightmicroscopic examination confirmed mesangial proliferative glomerulonephritis in all 9. Independently of the renal virus titre, viruria was found in 8 cases.
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Streitman, K., Beregi, E., Hollós, I. et al. Herpes immune complex nephritis. Pediatr Res 14, 1014 (1980). https://doi.org/10.1203/00006450-198008000-00243
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DOI: https://doi.org/10.1203/00006450-198008000-00243
