Abstract
To prevent hepatitis B (HB) infection in the pediatric hemodialysis unit, 8 children with chronic renal failure were immunized by means of a vaccine. Three children dialysed in the same unit were hepatitis B surface antigen (HBsAg) chronic carriers and represented a permanent high risk of HB infection for the whole unit. The vaccine was prepared by purification of HBsAg from human sera and was formalin inactivated. The children received 3 injections of vaccine at one month interval. Monthly screening of seric transaminases (ALT, AST) and markers of HB virus (HBsAg, anti-HBs, anti-HBc) was performed.
The 8 vaccinated children were followed from 3 to 17 months after vaccination. All of them seroconverted for anti-HBs. None of the children evidenced clinical, biological or serological sign of active HB infection. Hepatitis B vaccine in children with chronic renal failure appeared to be safe and its potency satisfactory. Presence of anti-HBs and absence of HB infection in vaccinated children suggest that this vaccine represents an efficient method of prevention against HB infection in high risk setting.
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Nivet, H., Drucker, J., Maupas, P. et al. VACCINE AGAINST HEPATITIS B IN CHILDREN WITH RENAL FAILURE. Pediatr Res 14, 1014 (1980). https://doi.org/10.1203/00006450-198008000-00248
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DOI: https://doi.org/10.1203/00006450-198008000-00248
