Abstract
CSF-protein profiles of 25 children with acute cerebellar ataxia and of 14 patients with a medulloblastoma at diagnosis were examined by quantitative zone electrophoresis in agarose gel. The profiles were compared with those obtained from a control group of 86 children and those from 61 patients with acute aseptic meningitis. The data from the latter group demonstrated the CSF-protein pattern of partial blood-CSF barrier (B-CSF-B) breakdown. The children with acute cerebellar ataxia showed no or only minor signs of a B-CSF-B impairment. However, CSF changes indicative of a severe lesion of B-CSF-B occurred in 9 out of 14 children with a medulloblastoma. A striking finding was that 12 patients revealed a marked increase of CSF-gammaglobulin. In 5 children this finding was associated with only a slight disturbance of B-CSF-B. Moreover, in 5 of the children with medulloblastoma oligoclonal CSF gammaglobulins could be detected clearly indicating local immunoglobulin synthesis within the CNS. Acute cerebellar ataxia can be differentiated from medulloblastoma by means of CSF-protein electrophoresis. The occurrence of oligoclonal gammaglobulins in medulloblastomas could mean synthesis of antibodies against tumour tissue.
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Siemes, H., Siegert, M. & Hanefeld, F. THE CSF-PROTEIN PATTERNS IN CHILDREN WITH ACUTE CEREBELLAR ATAXIA AND WITH MEDULLOBLASTOMAS. Pediatr Res 14, 1423 (1980). https://doi.org/10.1203/00006450-198012000-00090
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DOI: https://doi.org/10.1203/00006450-198012000-00090
