Abstract
The authors took into consideration the criteria of chemical diabetes according to Guthrie. In case of 17 children by p.os GTT were measured beside the usual blood glucose-, and serum Insulin levels, /ELISA; Boehringer/ the gamma /C/-peptide /Byk Mallinekrodt RIA/ values, too. The results of C-peptide tests in the various groups were the following: chemical diabetes without obesity /0-30-etc-180 min./:1.27±0.28; 3.77±1.2; 5.28±1.84; 4.88±0.96; 4.01±0.97; 3.96±1.1; 2.53±1.05 ng/ml; chemical diabetes with obesity: 2.41 ±0.56; 7.02±2.04; 7.48±1.9; 8.24±2.55; 8.91±2.95; 8.18±2.67; 7.23±2.31 ng/ml; obesity without chemical diabetes; 2.13±0.62; 6.46±1.67; 7.15±2.07; 7.45±1.96; 6.78±1.38; 6.06±2.11 ng/ml. If besides the means also the individual curves are analised it can be stated that a./the normalisation of blood glucose curves according to Guthrie is usually not parallel with the normalisation of insulin and C-peptide curves; b./the chemical diabetes without obesity, however, is usually coupled with normal insulin and C-peptide answere assuring the assumption that other factors provoke pathological glucose metabolism; c./it also ocours rarely that the insulin and C-peptide curves are not parallel.
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Blatniczky, L., Péter, F. & Pozderka, B. Gamma peptide examinations in chemical diabetes. Pediatr Res 15, 88 (1981). https://doi.org/10.1203/00006450-198101000-00105
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DOI: https://doi.org/10.1203/00006450-198101000-00105
