738 PARENT-CHILD CORONARY HEART DISEASE RISK FACTOR ASSOCIATIONS

Abstract

Parent-child (P-C) coronary heart disease (CHD) risk factor (RF) associations were assessed in 430 P-C pairs in the Princeton School Study. P-C correlations of Quetelet index (Q), systolic and diastolic blood pressure (SBP,DBP), plasma total cholesterol (TC), triglyceride (TG), low, high, and very low density lipoprotein cholesterol (C-LDL, C-HDL, C-VLDL) were [Pearson's(PE), Spearman's(S) r, ^*p<.05,^**<.02,^***<.01,+<.001]

P-C RF relationships were most marked for TC, C-LDL, C-HDL,and Q. P-C associations for C-HDL,C-LDL, and Q were also examined by covariance analysis. C-HDL in P and C were positively related; the following interactions were significant:holding P C-HDL constant, P TG was inversely related to C C-HDL; holding C age constant, P Q was inversely related to C C-HDL; by race group, P SBP related inversely with C C-HDL. C C-LDL positively related to P Q, and inversely with P SBP. Holding P TC constant, P C-HDL was inversely related to C C-LDL. P Q and TG were positively related to C Q. Holding P C-HDL constant, P TC was positively related to C Q. Holding P age constant, P C-HDL was inversely related to C Q. Aggregation of P-C RF may account, in part, for the familial clustering of CHD. Knowledge of parental CHD RF should facilitate early identification of CHD RF in their progeny.

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