Abstract
Eosinophilia (EOS) is seen after bone marrow transplantation (BMT) and has been described in several case reports of graftversus-host disease (GVHD). Increased numbers of eosinophils (Eo) are also seen in skin, liver and bone marrow biopsies from patients with GVHD. EOS is often associated with in vivo neutropenia and inhibits in vitro granulopoiesis. EOS was examined in 74 BMT patients and correlated with the incidence of GVHD and polymorpho-nuclear granulocyte (PMN) recovery. EOS (weekly average > 10%) was seen in 6/33 syngeneic patients (S), 10/27 syngeneic patients with GVHD (S/GVH) and 2/14 autologous/allogeneic patients (A/A). These incidences are not significantly different. Of the 16 patients with EOS, 9/16 had GVHD (P<.01). When the weekly average was >20%, 6/8 patients had GVHD (P<.025). The averages of the maximum weekly Eo percentages (mean±SD) for each group were 7.9±8.6% (S), 13.8±15.9% (S/GVH) and 6.0±9.2% (A/A) (P>.05). EOS did not correlate with the severity of GVHD. In 8 patients where the weekly Eo percentage was >20%, there were significant negative correlations between weekly PMN and Eo percentages (P<.02), as well as weekly changes in PMN and Eo counts (P<.01) and percentages (P<.001). PMN and Eo recovery after BMT may be interrelated, EOS after BMT is suggestive of GVHD and may be a helpful criterion in diagnosing the presence, but not the severity of GVHD.
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Bender, J., Saral, R. & Schwartz, E. 788 EOSINOPHILIA AFTER BONE MARROW TRANSPLANTATION. Pediatr Res 15 (Suppl 4), 573 (1981). https://doi.org/10.1203/00006450-198104001-00812
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DOI: https://doi.org/10.1203/00006450-198104001-00812
