Abstract
Chemotaxis and chemokinesis of MP under agarose were evaluated in 38 children with Down's syndrome and compared to that of 43 age-matched normal children and 21 healthy adults. Blood MP were obtained on Ficoll-Hypaque gradients, and migration towards a well containing zymosan-activated fresh normal human serum and a well filled with control serum was measured after staining and photographic magnification of the plates. Chemokinesis was evaluated in plates containing 8% zymosan-activated serum homogeneously dissolved in the agarose. The chemotactic index of MP from children with Down's syndrome was 1.2 ± 0.1 (mean ± S.D.) and was significantly (p <0.001) smaller than that of normal children (1.5 ± 0.2), or normal adults (1.43 ± 0.2). Chemokinesis of MP from children with Down's syndrome (8.4 mm ± 0.8 mm) was not different from that of normal children (7.6 mm ± 0.4 mm), but both were significantly weaker (p <0.001) than that of adult MP (13.0 mm ± 1.1 mm). These defects in MP movement may contribute to the deficient cell-mediated immunity found in children with Down's syndrome and thus to the increased susceptibility of these children to certain infections.
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Kretschmer, R., Barroeta, O., Nungaray, M. et al. 939 CHEMOTAXIS AND CHEMOKINESIS OF MONONUCLEAR PHAGOCYTES (MP) IN DOWN'S SYNDROME. Pediatr Res 15 (Suppl 4), 599 (1981). https://doi.org/10.1203/00006450-198104001-00964
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DOI: https://doi.org/10.1203/00006450-198104001-00964
