Abstract
PGs have been implicated as agents that affect membrane transport of numerous substances, yet little is known of the role of PGs on AA membrane transport. We examined the effects of PGE2 and PGF2α on AA transport by the A, ASC and L systems. Fibro-blasts were preincubated with PGE2 or PGF2α for 10 min prior to addition of the labeled AA.
PGE2 stimulated the uptake of all AA carrier systems while PGF2α inhibited all AA transport except for alanine which has high affinity for the A system. Our studies suggest 1) PGE2 and PGF2α have opposing, dose dependent actions on the L and ASC systems (valine/cycloleucine and glycine respectively) but have the same effect on the A system (alanine) and 2) PGE2 and PGF2α may act as an autoregulatory mechanism controlling AA membrane transport in cells. Supported in part by NIH Grant HL 23773 and the Cystic Fibrosis Foundation.
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Revsin, B., Stein, E. & Lemen, R. 1176 DIFFERENTIAL EFFECT OF PROSTAGLANDINS (PG) ON AMINO ACID (AA) TRANSPORT IN HUMAN FIBROBLASTS. Pediatr Res 15 (Suppl 4), 638 (1981). https://doi.org/10.1203/00006450-198104001-01202
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DOI: https://doi.org/10.1203/00006450-198104001-01202
