Abstract
The individual rate and velocity of excretion of INH vary according to the genetic structure of human populations.This characteristic corresponds to a bimodal distribution and is autosomally inherited.
Tuberculosis is still the most common infectious disease in Bolivia, and, INH is the most inexpensive anti-mycobacterial drug used in long term therapy.
We are studying an aymara mixed infant and adult population that is under treatment for tuberculosis and are receiving INH.
Our results show that only 44.1% of these patient are slowly inactivators for isoniazid , while, in the United States in caucasoid and negro population they correspond to 92.2% and 93.2% respectively (Evans et al., 1961).
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Taboada, G., Serrano, C., Claure, M. et al. 6 Isoniazid acetylation in an aymara mixed population from La Paz-Bolivia. Pediatr Res 15, 176 (1981). https://doi.org/10.1203/00006450-198102000-00026
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DOI: https://doi.org/10.1203/00006450-198102000-00026
