Abstract
In order to simulate the blood gas conditions in RDS of preterm newborn infants and evaluate the effect of the position of the Hb O2 dissociation curve (ODC) on tissue O2 and cardiac function, studies were carried out on newborn lambs less than 48 hr of age. Twenty-eight animals were divided up into two groups based on their ODC (a) high affinity: P50 20.5mmHg, and (b) low affinity: P50 32.3mmHg (by an exchange transfusion with adult blood). These two groups were then subdivided and ventilated under the following conditions: (I) 10% O2, 10% CO2, 80% N2, and (II) 8% O2, 92% N2, for 90 min. Blood gases, arterio-venous O2 content differences (A-V), cardiac output, ml/kg/min (CO) and O2 consumption, ml/kg/min (VO2) were determined. The results are means ± SD of paired values.
Hypoxia and hypercapnia resulted in an increase in CO (p < 0.025) and a decrease in VO2 (p<0.005). In severe hypoxia VO2 decreased (p<0.001). These changes occurred irrespective of the position of the ODC.
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Bard, H., Ameringen, MR., Fouron, JC. et al. 1235 THE EFFECT OF HIGH AND LOW O2 AFFINITY BLOOD DURING CONDITIONS OF COMBINED HYPOXIA HYPERCAPNIA, AND SEVERE HYPOXIA IN NEWBORN LAMBS. Pediatr Res 15 (Suppl 4), 648 (1981). https://doi.org/10.1203/00006450-198104001-01262
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DOI: https://doi.org/10.1203/00006450-198104001-01262
