Abstract
Two consecutive 12 hour period's creatinine excretion was longitudinally studied in 30 premature appropriate-for-gestational age infants, who were of 26 to 34 weeks gestation. This study was undertaken to determine whether there was variation in creatinine excretion (expressed as mg/kg/hour) for infants between 26-30 weeks which is different than for infants between 30-34 weeks. Creatinine excretion was significantly lower (p <.05) in the more immature group. This difference was only apparent at 1-3 days postnatal age and disappeared by 10-15 days postnatal age. We also demonstrated considerable variation in creatinine excretion between two consecutive 12 hour periods.
We suggest that creatinine clearance determinations based on short time period urine collections and creatinine excretion may not accurately represent 24 hour creatinine clearance in prematures.
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Bhat, A., Scanlon, J. 1250 VARIATION IN CREATININE EXCRETION DURING 24 HOUR PERIODS IN PRETERM INFANTS. Pediatr Res 15 (Suppl 4), 651 (1981). https://doi.org/10.1203/00006450-198104001-01277
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DOI: https://doi.org/10.1203/00006450-198104001-01277
