Abstract
CO, tpH, and BL changes were studied in 8 puppies during acute hypovolemia and reinfusion . Hypovolemia was induced by bleeding 20 ml/kg of blood. Mean blood pressure (MBP),heart rate (HR) and tpH were monitored continuously. CO, BL and arterial blood gases were analyzed every 15′ during the study. After 30′ hypovolemia blood was reinfused and all the above parameters were monitored for the next 30′ cO, and tpH decreased significantly during hypovolemia. Changes in MBP were transient and minimal. The fall in tpH was greater than ApH (p<.05) and its recovery slower than ApH. EL correlated better with tpH(r= −0.58, p<.005). Following reinfusion CO, HR, ApH returned to baseline but tpH lagged behind. Summary: 1) In acute hypovolemia tpH was a better indicator of CO and peripheral metabolism than MBP. 2) Slow recovery of tpH following reinfusion could be due to slow clearance of tissue lactate. These data indicate that tpH will be useful in detecting and treating impending or existing shock. (Data in M±S.E)
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Bhat, R., Braverman, B., Justice, P. et al. 1252 TISSUE pH, (TpH), CARDIAC OUTPUT (CO)BLOOD LACTATE(BL) CHANGES FOLLOWING ACUTE HYPOVOLEMIA IN PUPPIES. Pediatr Res 15 (Suppl 4), 651 (1981). https://doi.org/10.1203/00006450-198104001-01279
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DOI: https://doi.org/10.1203/00006450-198104001-01279
