Abstract
Many statistical parameters have been used to quantify NHRV, but little comparison has been made of their relative ability to predict the infant's clinical course. In this study seven previously described parameters of short term variability (STV) and five of long term variability (LTV) were computed from 2225 hrs of electrocardiogram from 101 infants aged 1-72 hours.
We found close correlations between all measured parameters of NHRV. No one parameter proved clinically superior at all ages studied for prediction of severity of respiratory distress or subsequent mortality. However, a combination of parameters by multiple regression or discriminant analysis led to accurate prediction of clinical course. Factor analysis revealed underlying relationships between the studied parameters of NHRV, and 3 hypothetical factors were derived which retained much of the predictive ability of the 12 original parameters. In addition we found that NHRV was lower in infants of lower gestational age (GA) and birthweight, and for STV but not LTV this could not be fully accounted for by associated differences in heart rate. NHRV of infants who were small for GA was in keeping with GA and not birthweight.
We conclude that a combination of NHRV parameters is of greater clinical predictive value than any single parameter.
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Jenkins, J., Mcclure, G., Mitchell, H. et al. 1332 COMPARISON OF CLINICAL PREDICTIVE VALUE OF TWELVE MEASURES OF NEONATAL HEART RATE VARIABILITY (NHRV). Pediatr Res 15 (Suppl 4), 665 (1981). https://doi.org/10.1203/00006450-198104001-01361
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DOI: https://doi.org/10.1203/00006450-198104001-01361
