Abstract
In an effort to decrease barotrauma, air leaks, and subsequent chronic lung disease we investigated ventilation of infants with HMD on lower PIP. MAP was held constant since it is a prime determinant of oxygenation and ventilation. We studied ten stable, unparalyzed infants with HMD on time cycled, pressure limited ventilators (Baby Bird). They were between 820-3060 gms, 24-82 hours old and on an FI02 of .30-.80. MAP, PIP, inspiratory time (ti) and ventilator rate (f) were determined for each infant (Baseline (B)). PIP was then lowered by 30% and f increased by decreasing the expiratory time to maintain MAP constant (Study (S)). End expiratory pressure, FIO2 and ti were not changed. Each infant was studied in the following sequence: B-S-B-S-B for 20 minutes at each setting. The results, as mean values, are shown in the following table:
There was no significant difference in B or S blood gases (ABG).
We conclude that stable, unparalyzed infants with HMD may be mechanically ventilated at lower PIP with no change in ABG's if MAP is held constant.
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Ratner, I., Hernandez, J., Accurso, F. et al. 1400 LOW PEAK INSPIRATORY PRESSURES (PIP) FOR VENTILATION OF INFANTS WITH HYALINE MEMBRANE DISEASE (HMD). Pediatr Res 15 (Suppl 4), 676 (1981). https://doi.org/10.1203/00006450-198104001-01429
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DOI: https://doi.org/10.1203/00006450-198104001-01429
