1483 FUROSEMIDE (F) ANTAGONISM OF INDOMETHACIN (I) EFFECT ON RENAL FUNCTION

Abstract

To evaluate if (F) would prevent the adverse renal effects of I.V.(I), 9 premature infants with PDA were randomized into 2 groups; 4 received 1(0.3mg/kg) alone and 5, I and F (lmg/kg I.V.) simultaneously. There were no slg. differences between the groups in B.W.(mean±S.D, 1179±456 vs 1021±282gm), gest,age(31.3±2.2 vs 29.5±1.9wks), postn. age (9.0±2.9 vs 11.6±0.5d.), clinical cardiovascular status, pH, F10₂, pO₂ and pCO₂.

Three in I and 4 in I+F responded with closure of PDA. There were no sig. differences in renal function between the groups. However, when compared with baseline, sig. decreases in urine output, GFR and C-H₂O were seen when I was used alone but not when I+F were given simultaneously. The addition of F did not affect FeNa. These changes suggest that F may be useful in preventing oliguria by overriding the action of I.

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