Abstract
The developement of immunocomplex-related pathology during type B viral hepatitis is well known.HBsAg positive subjects can be affected by glomerulonephritis,usually of the membranous type; HBsAg-antiHBs immunocomplexes (I.C.)have been found in these patients'kidneys. Some authors believe that other I.C. may cause this pathology (Kleinkneoht, 1979). Our patient is a 3-years old boy polytransfused because of hemophilia A,with chronic active hepatitis, who developed nephrotic syndrome at the same time that factor VIII inhibitor was produced. The presence of the inhibitor has not been previously described as a cause for I.C. related pathology. In view of our data, we can formulate the hypothesis that factor VIII-inhibitor I.C. caused the renal disease, at the moment when the R.E.S. was saturated by the HBsAg-antiHBs complexes. It seems advisable to carefully monitor the renal function in hemophilic patients when they develope inhibitor, in particular if they also have persistent hepatitis.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Borzanl, M., Migliavacoa, O. & Longhi, R. 1485 NEPHROTIC SINDROME IN A CHILD WITH HEMOPHILIA AND PERSISTENT HEPATITIS: A PATHOGENETIC HYPOTHESIS. Pediatr Res 15 (Suppl 4), 690 (1981). https://doi.org/10.1203/00006450-198104001-01514
Issue date:
DOI: https://doi.org/10.1203/00006450-198104001-01514
This article is cited by
-
A child diagnosed with severe hemophilia A presenting with nephrotic syndrome: a case report
Journal of Medical Case Reports (2023)