Abstract
HS complicates management of TR and limits immunosuppression, jeopardizing graft function. Splenectomy affords variable benefit but imposes risks of major surgery and potential infectious complications in immunosuppressed subjects. 3 TR and 1 patient awaiting transplantation developed severe leukopenia and/or thrombocytopenia and splenomegaly, not corrected by discontinuing possible offending drugs. 65-95% splenic infarction with Gelfoam particles were performed.
In the TR improved hematologic parameters allowed increased immunosuppression and stable, or improved, graft function. Complications (fever, pain, ileus, hematoma) were not serious.
PSE offers significant advantages to these patients, avoids major surgery, and has proven effective in treatment of HS.
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Macdonell, R., Gerlock, A., Parris, W. et al. 1521 HYPERSPLENISM(HS) IN RENAL TRANSPLANT RECIPIENTS(TR): THERAPY WITH PARTIAL SPLENIC EMBOLIZATION(PSE). Pediatr Res 15 (Suppl 4), 696 (1981). https://doi.org/10.1203/00006450-198104001-01544
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DOI: https://doi.org/10.1203/00006450-198104001-01544
